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LAST CHANCE!
If you are looking to be a part of a community of like-minded practitioners and receive guidance on navigating the nuances of real-world functional medicine, click the button below to learn more and apply!
And this is the last chance to join the FMC Collective to receive two complementary 1:1 mentor calls with me!
What's coming up in July? Quizzes to test your knowledge, Focused Mastery Workshops on ApoB and Glucose dynamics, introduction to an app that can assist in clinical application of functional medicine, and more!
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This week's topic: Triglycerides and VLDL
Overview of today's email:
- Overview of triglycerides and VLDL
- Clinical Pearls
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1. Triglycerides and VLDL
Some reminders about triglycerides:
- Triglyceride half life is around 1 hour
- Something you may not know: All lipoproteins (LDL, HDL, VLDL, IDL) contain triglycerides; they also have proteins, phospholipids, and cholesterol
- The diagram below (from Metabolic Fitness Pro) is a great reminder and overview of lipid metabolism and transport around the body
Some reminders about VLDL:
- VLDL half life is around 5-6 hours
- The purpose of VLDL is to deliver triglycerides to adipose, skeletal muscle, and cardiac tissues (for a source of energy), or to HDL [source]
- Around 50-70%% of VLDL particles are made up of triglycerides
- Synthesis of VLDL by the liver is increased with alcohol use, estrogen use, and in hypothyroidism
- VLDL shrinks in size as it releases its contents: VLDL --> IDL --> LDL
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2. Clinical Pearls
Triglycerides:
- Optimal Triglyceride levels: 70-90 mg/dL
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Did you know low levels of triglycerides can be detrimental? If low levels of triglycerides (under 70 mg/dL), consider:
- Autoimmunity
- Low dietary fat intake
- Dysfunctional absorption (especially from issues with bile, pancreatic function, competitive binding with calcium or magnesium)
VLDL:
To lower VLDL (which also applies to lowering triglycerides):
- 95% of VLDL synthesis is from dietary lipid intake (saturated fats and trans fats), so reducing these can help
- Increase physical activity
- Make sure a patient is not consuming excessive carbohydrate/sugar intake
- Address estrogen use especially if other CV risk factors are present (e.g. OCP), hypothyroidism (affects lipid clearance), alcohol use, and insulin resistance
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I hope this was clinically useful!
Next newsletter topic: ApoB and Lp(a).
Meg
Additional resources that may be helpful
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